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Bupropion can be an example of an antidepressant with an amphetamine-like framework comparable to ephedrine, and it truly is an NDRI. Its motion bears much more resemblance to amphetamine than to fluoxetine in that its Principal method of therapeutic motion includes norepinephrine also to a lesser diploma dopamine, but In addition it releases some serotonin from presynaptic clefts. It shouldn't be used with ephedrine, as it may enhance the likelihood of Negative effects.

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